With respect to the main role of amyloid-β (Aβ) plaques as one of the pathological hallmarks in the brain of Alzheimer’s patients, the development of new imaging probes for targeted detection of Aβ plaques has attracted considerable interests. In this study, a novel cyclopentadienyl tricarbonyl Technetium-99 m (99mTc) agent with peptide scaffold, 99mTc-Cp-GABA-D-(FPLIAIMA)-NH2, for binding to the Aβ plaques was designed and successfully synthesized using the Fmoc solid-phase peptide synthesis method.
This radiopeptide revealed a good affinity for Aβ42 aggregations (Kd = 20 µM) in binding affinity study and this result was confirmed by binding to Aβ plaques in brain sections of human Alzheimer’s disease (AD) and rat models using in vitro autoradiography, fluorescent staining, and planar scintigraphy. Biodistribution studies of radiopeptide in AD and normal rats demonstrated a moderate initial brain uptake about 0.38 and 0.35% (ID/g) 2 min post-injection, respectively.
Whereas, AD rats showed a notable retention time in the brain (0.23% ID/g at 30 min) in comparison with fast clearance in normal rat brains. Normal rats following treatment with cyclosporine A as a p-glycoprotein inhibitor showed a significant increase in the radiopeptide brain accumulation compared to non-treated ones.
Mouse SKT shRNA Plasmid |
20-abx980555 |
Abbexa |
|
|
|
Mouse pre-microRNA Expression Construct mir-124-1 |
MMIR-124-1-PA-1 |
SBI |
Bacterial Streak |
EUR 684 |
|
Mouse pre-microRNA Expression Construct mir-124-2 |
MMIR-124-2-PA-1 |
SBI |
Bacterial Streak |
EUR 684 |
|
Mouse pre-microRNA Expression Construct mir-124-3 |
MMIR-124-3-PA-1 |
SBI |
Bacterial Streak |
EUR 684 |
|
ALCAM Recombinant Protein |
96-124 |
ProSci |
0.2 mg |
EUR 490.25 |
Description: CD166 antigen is a 100-105 kD typeI transmembrane glycoprotein that is a member of the immunoglobulin superfamily of proteins, which is also known as Activated leukocyte cell adhesion molecule (ALCAM) in human, SC-1/DM-GRASP/BEN in the chicken, and KG-CAM in the rat. CD166 is a cell adhesion molecule that binds to CD6. CD166 involved in neurite extension by neurons via heterophilic and homophilic interactions. |
Augmedium™, Powder 500 |
124 |
AthenaES |
500 ml |
EUR 566 |
Human beta-defensin 124 (BD124) ELISA Kit, 96 tests, Quantitative |
100-280-BD124 |
Alpha Diagnostics |
1 Kit |
EUR 895 |
Mouse Sickle tail protein (SKT) ELISA Kit |
abx389166-96tests |
Abbexa |
96 tests |
EUR 911 |
|
CHIR-124 |
E1KS2683 |
EnoGene |
2mg1 PHYSICAL AND CHEMICAL PROPERTIES |
EUR 325 |
CHIR-124 |
A8394-25 |
ApexBio |
25 mg |
EUR 340 |
Description: CHIR-124, a selective inhibitor, inhibits Chk1 with IC50 value of 0.3nM 2,000-fold more potently than Chk2 with IC50 value of 0.7?M. |
CHIR-124 |
A8394-5 |
ApexBio |
5 mg |
EUR 151 |
Description: CHIR-124, a selective inhibitor, inhibits Chk1 with IC50 value of 0.3nM 2,000-fold more potently than Chk2 with IC50 value of 0.7?M. |
CHIR-124 |
A8394-5.1 |
ApexBio |
10 mM (in 1mL DMSO) |
EUR 160 |
Description: CHIR-124, a selective inhibitor, inhibits Chk1 with IC50 value of 0.3nM 2,000-fold more potently than Chk2 with IC50 value of 0.7?M. |
CHIR-124 |
A8394-50 |
ApexBio |
50 mg |
EUR 537 |
Description: CHIR-124, a selective inhibitor, inhibits Chk1 with IC50 value of 0.3nM 2,000-fold more potently than Chk2 with IC50 value of 0.7?M. |
FPA 124 |
B7222-10 |
ApexBio |
10 mg |
EUR 241 |
FPA 124 |
B7222-25 |
ApexBio |
25 mg |
EUR 457 |
FPA 124 |
B7222-5 |
ApexBio |
5 mg |
EUR 158 |
EUK 124 |
C4679-10 |
ApexBio |
10 mg |
EUR 132 |
Human Sickle tail protein homolog, SKT ELISA KIT |
ELI-18163h |
Lifescience Market |
96 Tests |
EUR 824 |
miRZip-124 anti-miR-124 microRNA construct |
MZIP124-PA-1 |
SBI |
Bacterial Streak |
EUR 684 |
|
hCRP FRET 96 |
CH1021-96 |
Mediomics |
1 Kit |
EUR 455 |
hCRP TRF 96 |
CHTR1021-96 |
Mediomics |
1 Kit |
EUR 482 |
hInsulin FRET 96 |
IH1017-96 |
Mediomics |
1 Kit |
EUR 455 |
hInsulin TRF 96 |
IHTR1017-96 |
Mediomics |
1 Kit |
EUR 482 |
hAlbumin FRET 96 |
AH1005-96 |
Mediomics |
1 Kit |
EUR 455 |
hAlbumin TRF 96 |
AHTR1005-96 |
Mediomics |
1 Kit |
EUR 482 |
mIgG TRF 96 |
MIGTR1020-96 |
Mediomics |
1 Kit |
EUR 482 |
rIgG FRET 96 |
RI1024-96 |
Mediomics |
1 Kit |
EUR 455 |
Skt ELISA Kit| Mouse Sickle tail protein ELISA Kit |
EF014796 |
Lifescience Market |
96 Tests |
EUR 689 |
HSP70 ELISA Kit |
SKT-105-96 |
Cusabio |
1 plate of 96 wells |
EUR 581 |
|
Description: Sandwich ELISA kit used for quantitate HSP70 concentration in Cell Lysates, Tissue, Serum, Urine samples from Human, Goat, Dog |
HSC70 ELISA Kit |
SKT-106-96 |
Stressmarq |
1 plate of 96 wells |
EUR 717 |
|
Description: Sandwich ELISA kit used for quantitate HSC70 concentration in Cell Lysates, Tissue, Serum, Whole Blood samples from Human, Avian |
HSP90 alpha ELISA Kit |
SKT-107-96 |
Stressmarq |
1 plate of 96 wells |
EUR 685 |
|
Description: Sandwich ELISA kit used for quantitate HSP90 alpha concentration in Cell Lysates, Tissue, Serum, Whole Blood samples from Human, Goat, Avian |
HSP70 ELISA Kit (High-Sensitivity) |
SKT-108-96 |
Stressmarq |
1 plate of 96 wells |
EUR 685 |
|
Description: Sandwich ELISA kit used for quantitate HSP70 concentration in Serum, Plasma, Cell Lysates, Tissue samples from Human, Monkey, Dog, Rat, Mouse |
HSP27 ELISA Kit |
SKT-109-96 |
Stressmarq |
1 plate of 96 wells |
EUR 585 |
|
Description: Sandwich ELISA kit used for quantitate HSP27 concentration in Serum, Plasma, Cell Lysates, Tissue samples from Human |
HSP60 ELISA Kit |
SKT-110-96 |
Stressmarq |
1 plate of 96 wells |
EUR 585 |
|
Description: Sandwich ELISA kit used for quantitate HSP60 concentration in Cell Lysates, Tissue, Serum samples from Human |
HO-1 ELISA Kit |
SKT-111-96 |
Stressmarq |
1 plate of 96 wells |
EUR 585 |
|
Description: Sandwich ELISA kit used for quantitate HO-1 concentration in Cell Lysates, Tissue, Serum, Cyst fluid samples from Human, Rat |
HSP65 ELISA Kit |
SKT-113-96 |
Stressmarq |
1 plate of 96 wells |
EUR 633 |
|
Description: Sandwich ELISA kit used for quantitate M bovis/M tuberculosum HSP65 concentration in human samples in Cell Lysates, Tissue, Serum samples from M bovis, M tuberculosum |
Alpha B Crystallin ELISA Kit |
SKT-123-96 |
Stressmarq |
1 plate of 96 wells |
EUR 717 |
|
Description: Sandwich ELISA kit used for quantitate alpha B crystallin concentration in Cell Lysates, Tissue, Serum samples from Human |
Nitrotyrosine ELISA Kit |
SKT-126-96 |
Stressmarq |
1 plate of 96 wells |
EUR 460 |
|
Description: Competitive ELISA kit used for quantitate Nitrotyrosine in Plasma, Serum, Cell Lysates, Urine samples from all species |
Rat GRP78 ELISA Kit |
SKT-137-96 |
Stressmarq |
1 plate of 96 wells |
EUR 632 |
|
Description: Sandwich ELISA kit used for quantitate GRP78 concentration in rat samples in Tissue samples from Rat |
Dibromo-tyrosine ELISA Kit |
SKT-140-96 |
Stressmarq |
1 plate of 96 wells |
EUR 566 |
|
Description: Competitive ELISA kit used to quantify free and protein-bound 3,5-dibromotyrosine in Plasma, Urine samples from all species |
Cortisol EIA Kit |
SKT-201-96 |
Stressmarq |
1 plate of 96 wells |
EUR 329 |
|
Description: Competitive EIA kit used for quantitative measuring cortisol present in Dried Fecal Samples, Saliva, Urine, Serum, EDTA Plasma, Heparin Plasma, Tissue Culture Media samples from all species |
Glutathione Detection Kit |
SKT-202-96 |
Stressmarq |
1 plate of 96 wells |
EUR 428 |
|
Description: Direct Fluorometric detection assay to measure the total GSH content in Whole Blood, Serum, EDTA Plasma, Heparin Plasma, Erythrocytes, Urine, Cell Lysates, Tissue samples from all species |
Glutathione S-Transferase Activity Kit |
SKT-203-96 |
Stressmarq |
1 plate of 96 wells |
EUR 428 |
|
Description: Enzyme Activity Fluorometric assay used for quantitative measuring the activity of glutathione S-transferase in Urine, Serum, EDTA Plasma, Heparin Plasma, Cell Lysates samples from Human, Mollusk, Fish |
Glutathione Reductase Activity Kit |
SKT-204-96 |
Stressmarq |
1 plate of 96 wells |
EUR 428 |
|
Description: Enzyme Activity Fluorometric assay used for measuring glutathione reductase activity by the amount of GSH generated from the reduction of GSSG, in Serum, EDTA Plasma, Heparin Plasma, Erythrocytes, Cell Lysates samples from Human |
Corticosterone EIA Kit |
SKT-205-96 |
Stressmarq |
1 plate of 96 wells |
EUR 355 |
|
Description: Sandwich EIA kit used to measure the corticosterone present in Serum, EDTA Plasma, Heparin Plasma, Urine, Tissue Culture Media, Dried Fecal Samples samples from all species |
Cortisone CLIA Kit |
SKT-206-96 |
Stressmarq |
1 plate of 96 wells |
EUR 467 |
|
Description: Sandwich CLIA kit used for quantitative measuring the cortisone present in Dried Fecal Samples, Serum, Saliva, Urine, Plasma, Tissue Culture Media samples from all species |
Prostaglandin E2 EIA Kit |
SKT-207-96 |
Stressmarq |
1 plate of 96 wells |
EUR 527 |
|
Description: Sandwich EIA kit used for quantitative measuring PGE2 present in Saliva, Urine, Serum, EDTA Plasma, Heparin Plasma, Tissue Culture Media samples from all species |
Cyclic AMP CLIA Kit (High-Sensitivity) |
SKT-208-96 |
Stressmarq |
1 plate of 96 wells |
EUR 494 |
|
Description: Direct CLIA kit used for quantitative measuring cAMP present in Cell Lysates, Tissue, Saliva, Urine, EDTA Plasma, Heparin Plasma, Tissue Culture Media samples from all species |
Cyclic AMP EIA Kit |
SKT-209-96 |
Stressmarq |
1 plate of 96 wells |
EUR 454 |
|
Description: Direct EIA kit used for quantitative measuring cAMP present in Cell Lysates, Tissue, Saliva, Urine, EDTA Plasma, Heparin Plasma, Tissue Culture Media samples from all species |
Cyclic GMP CLIA Kit (High-Sensitivity) |
SKT-210-96 |
Stressmarq |
1 plate of 96 wells |
EUR 520 |
|
Description: Direct CLIA kit used to measure cGMP present in Cell Lysates, Tissue, Saliva, Urine, EDTA Plasma, Tissue Culture Media samples from all species |
Cyclic GMP EIA Kit |
SKT-211-96 |
Stressmarq |
1 plate of 96 wells |
EUR 474 |
|
Description: Direct EIA kit used for quantitative measuring cGMP present in Cell Lysates, Tissue, Saliva, Urine, EDTA Plasma, Tissue Culture Media samples from all species |
Nitric Oxide Detection Kit |
SKT-212-96 |
Stressmarq |
2 plates of 96 wells |
EUR 342 |
|
Description: Indirect Colorimetric assay used for quantitative measuring Nitrate and Nitrite present in a variety of samples in Serum, Plasma, Urine, Saliva, Water, Buffer, Cell Lysates, Tissue Culture Media samples from all species |
Retinol Binding Protein Urinary EIA Kit |
SKT-218-96 |
Stressmarq |
1 plate of 96 wells |
EUR 527 |
|
Description: Sandwich EIA kit used to measure RBP levels in urine samples in Urine samples from Human, Rat, Dog, Monkey |
Cystatin C EIA Kit |
SKT-219-96 |
Stressmarq |
1 plate of 96 wells |
EUR 494 |
|
Description: Sandwich EIA kit used to measure cystatin C levels in Serum, EDTA Plasma, Heparin Plasma, Urine, Tissue Culture Media samples from Human |
Tissue Culture Plate, 96 Well |
TCP20-96 |
Bio Basic |
1 UNIT |
EUR 53.48 |
|
Aligned Nanofibers 96 Well Plate |
3D00012-96 |
Neuromics |
700 nm-PCLs |
EUR 110 |
Bridge-It cAMP-PDE 96 |
PD1016-96 |
Mediomics |
1 Kit |
EUR 455 |
Rat Coiled coil domain containing protein 124(CCDC124) ELISA kit |
E02C1430-96 |
BlueGene |
1 plate of 96 wells |
EUR 685 |
|
Description: A sandwich ELISA for quantitative measurement of Rat Coiled coil domain containing protein 124(CCDC124) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rabbit Coiled coil domain containing protein 124(CCDC124) ELISA kit |
E04C1430-96 |
BlueGene |
1 plate of 96 wells |
EUR 685 |
|
Description: A sandwich ELISA for quantitative measurement of Rabbit Coiled coil domain containing protein 124(CCDC124) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse Coiled coil domain containing protein 124(CCDC124) ELISA kit |
E03C1430-96 |
BlueGene |
1 plate of 96 wells |
EUR 685 |
|
Description: A sandwich ELISA for quantitative measurement of Mouse Coiled coil domain containing protein 124(CCDC124) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Human Coiled coil domain containing protein 124(CCDC124) ELISA kit |
E01C1430-96 |
BlueGene |
1 plate of 96 wells |
EUR 685 |
|
Description: A sandwich ELISA for quantitative measurement of Human Coiled coil domain containing protein 124(CCDC124) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Pig Coiled coil domain containing protein 124(CCDC124) ELISA kit |
E07C1430-96 |
BlueGene |
1 plate of 96 wells |
EUR 685 |
|
Description: A sandwich ELISA for quantitative measurement of Porcine Coiled coil domain containing protein 124(CCDC124) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Goat Coiled coil domain containing protein 124(CCDC124) ELISA kit |
E06C1430-96 |
BlueGene |
1 plate of 96 wells |
EUR 685 |
|
Description: A sandwich ELISA for quantitative measurement of Goat Coiled coil domain containing protein 124(CCDC124) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Monkey Coiled coil domain containing protein 124(CCDC124) ELISA kit |
E09C1430-96 |
BlueGene |
1 plate of 96 wells |
EUR 685 |
|
Description: A sandwich ELISA for quantitative measurement of Monkey Coiled coil domain containing protein 124(CCDC124) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Dog Coiled coil domain containing protein 124(CCDC124) ELISA kit |
E08C1430-96 |
BlueGene |
1 plate of 96 wells |
EUR 685 |
|
Description: A sandwich ELISA for quantitative measurement of Canine Coiled coil domain containing protein 124(CCDC124) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
AKT1 (Ab-124) Antibody |
CSB-PA919481- |
Cusabio |
|
EUR 335 |
|
Description: A polyclonal antibody against AKT1 (Ab-124). Recognizes AKT1 (Ab-124) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:3000 |
AKT1 (Ab-124) Antibody |
CSB-PA919481-100ul |
Cusabio |
100ul |
EUR 316 |
|
Description: A polyclonal antibody against AKT1 (Ab-124). Recognizes AKT1 (Ab-124) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:3000 |
Akt (Ab-124) Antibody |
33129-100ul |
SAB |
100ul |
EUR 252 |
Akt (Ab-124) Antibody |
33129-50ul |
SAB |
50ul |
EUR 187 |
bcl-2(124) Antibody |
BNC040530-100 |
Biotium |
100uL |
EUR 199 |
Description: Primary antibody against bcl-2(124), CF405S conjugate, Concentration: 0.1mg/mL |
bcl-2(124) Antibody |
BNC040530-500 |
Biotium |
500uL |
EUR 544 |
Description: Primary antibody against bcl-2(124), CF405S conjugate, Concentration: 0.1mg/mL |
bcl-2(124) Antibody |
BNC470530-100 |
Biotium |
100uL |
EUR 199 |
Description: Primary antibody against bcl-2(124), CF647 conjugate, Concentration: 0.1mg/mL |
bcl-2(124) Antibody |
BNC470530-500 |
Biotium |
500uL |
EUR 544 |
Description: Primary antibody against bcl-2(124), CF647 conjugate, Concentration: 0.1mg/mL |
bcl-2(124) Antibody |
BNCAP0530-100 |
Biotium |
100uL |
EUR 199 |
Description: Primary antibody against bcl-2(124), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL |
bcl-2(124) Antibody |
BNCAP0530-500 |
Biotium |
500uL |
EUR 544 |
Description: Primary antibody against bcl-2(124), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL |
bcl-2(124) Antibody |
BNCB0530-100 |
Biotium |
100uL |
EUR 199 |
Description: Primary antibody against bcl-2(124), Biotin conjugate, Concentration: 0.1mg/mL |
bcl-2(124) Antibody |
BNCB0530-500 |
Biotium |
500uL |
EUR 544 |
Description: Primary antibody against bcl-2(124), Biotin conjugate, Concentration: 0.1mg/mL |
bcl-2(124) Antibody |
BNC810530-100 |
Biotium |
100uL |
EUR 199 |
Description: Primary antibody against bcl-2(124), CF680R conjugate, Concentration: 0.1mg/mL |
bcl-2(124) Antibody |
BNC810530-500 |
Biotium |
500uL |
EUR 544 |
Description: Primary antibody against bcl-2(124), CF680R conjugate, Concentration: 0.1mg/mL |
bcl-2(124) Antibody |
BNC700530-100 |
Biotium |
100uL |
EUR 199 |
Description: Primary antibody against bcl-2(124), CF770 conjugate, Concentration: 0.1mg/mL |
bcl-2(124) Antibody |
BNC700530-500 |
Biotium |
500uL |
EUR 544 |
Description: Primary antibody against bcl-2(124), CF770 conjugate, Concentration: 0.1mg/mL |
bcl-2(124) Antibody |
BNC880530-100 |
Biotium |
100uL |
EUR 199 |
Description: Primary antibody against bcl-2(124), CF488A conjugate, Concentration: 0.1mg/mL |
bcl-2(124) Antibody |
BNC880530-500 |
Biotium |
500uL |
EUR 544 |
Description: Primary antibody against bcl-2(124), CF488A conjugate, Concentration: 0.1mg/mL |
bcl-2(124) Antibody |
BNC940530-100 |
Biotium |
100uL |
EUR 199 |
Description: Primary antibody against bcl-2(124), CF594 conjugate, Concentration: 0.1mg/mL |
bcl-2(124) Antibody |
BNC940530-500 |
Biotium |
500uL |
EUR 544 |
Description: Primary antibody against bcl-2(124), CF594 conjugate, Concentration: 0.1mg/mL |
bcl-2(124) Antibody |
BNC610530-100 |
Biotium |
100uL |
EUR 199 |
Description: Primary antibody against bcl-2(124), CF660R conjugate, Concentration: 0.1mg/mL |
bcl-2(124) Antibody |
BNC610530-500 |
Biotium |
500uL |
EUR 544 |
Description: Primary antibody against bcl-2(124), CF660R conjugate, Concentration: 0.1mg/mL |
bcl-2(124) Antibody |
BNC680530-100 |
Biotium |
100uL |
EUR 199 |
Description: Primary antibody against bcl-2(124), CF568 conjugate, Concentration: 0.1mg/mL |
bcl-2(124) Antibody |
BNC680530-500 |
Biotium |
500uL |
EUR 544 |
Description: Primary antibody against bcl-2(124), CF568 conjugate, Concentration: 0.1mg/mL |