Synthesis, biological evaluation and preclinical study of a novel 99mTc-peptide: A targeting probe of amyloid-β plaques as a possible diagnostic agent for Alzheimer’s disease.

With respect to the main role of amyloid-β (Aβ) plaques as one of the pathological hallmarks in the brain of Alzheimer’s patients, the development of new imaging probes for targeted detection of Aβ plaques has attracted considerable interests. In this study, a novel cyclopentadienyl tricarbonyl Technetium-99 m (^99mTc) agent with peptide scaffold, ^99mTc-Cp-GABA-D-(FPLIAIMA)-NH₂, for binding to the Aβ plaques was designed and successfully synthesized using the Fmoc solid-phase peptide synthesis method.

This radiopeptide revealed a good affinity for Aβ42 aggregations (K_d = 20 µM) in binding affinity study and this result was confirmed by binding to Aβ plaques in brain sections of human Alzheimer’s disease (AD) and rat models using in vitro autoradiography, fluorescent staining, and planar scintigraphy. Biodistribution studies of radiopeptide in AD and normal rats demonstrated a moderate initial brain uptake about 0.38 and 0.35% (ID/g) 2 min post-injection, respectively.

Whereas, AD rats showed a notable retention time in the brain (0.23% ID/g at 30 min) in comparison with fast clearance in normal rat brains. Normal rats following treatment with cyclosporine A as a p-glycoprotein inhibitor showed a significant increase in the radiopeptide brain accumulation compared to non-treated ones.

Mouse SKT shRNA Plasmid
20-abx980555	Abbexa	EUR 801.00 EUR 1121.00	150 µg 300 µg

Mouse pre-microRNA Expression Construct mir-124-1
MMIR-124-1-PA-1	SBI	Bacterial Streak	EUR 684

Mouse pre-microRNA Expression Construct mir-124-2
MMIR-124-2-PA-1	SBI	Bacterial Streak	EUR 684

Mouse pre-microRNA Expression Construct mir-124-3
MMIR-124-3-PA-1	SBI	Bacterial Streak	EUR 684

ALCAM Recombinant Protein
96-124	ProSci	0.2 mg	EUR 490.25
Description: CD166 antigen is a 100-105 kD typeI transmembrane glycoprotein that is a member of the immunoglobulin superfamily of proteins, which is also known as Activated leukocyte cell adhesion molecule (ALCAM) in human, SC-1/DM-GRASP/BEN in the chicken, and KG-CAM in the rat. CD166 is a cell adhesion molecule that binds to CD6. CD166 involved in neurite extension by neurons via heterophilic and homophilic interactions.

Augmedium™, Powder 500
124	AthenaES	500 ml	EUR 566

Human beta-defensin 124 (BD124) ELISA Kit, 96 tests, Quantitative
100-280-BD124	Alpha Diagnostics	1 Kit	EUR 895

Mouse Sickle tail protein (SKT) ELISA Kit
abx389166-96tests	Abbexa	96 tests	EUR 911

Mouse Sickle tail protein, Skt ELISA KIT
ELI-29595m	Lifescience Market	96 Tests	EUR 865

FPA-124
HY-15369	MedChemExpress	5mg	EUR 394

CHIR-124
HY-13263	MedChemExpress	50mg	EUR 670

CHIR-124
E1KS2683	EnoGene	2mg1​ PHYSICAL AND CHEMICAL PROPERTIES	EUR 325

CHIR-124
A8394-25	ApexBio	25 mg	EUR 340
Description: CHIR-124, a selective inhibitor, inhibits Chk1 with IC50 value of 0.3nM 2,000-fold more potently than Chk2 with IC50 value of 0.7?M.

CHIR-124
A8394-5	ApexBio	5 mg	EUR 151
Description: CHIR-124, a selective inhibitor, inhibits Chk1 with IC50 value of 0.3nM 2,000-fold more potently than Chk2 with IC50 value of 0.7?M.

CHIR-124
A8394-5.1	ApexBio	10 mM (in 1mL DMSO)	EUR 160
Description: CHIR-124, a selective inhibitor, inhibits Chk1 with IC50 value of 0.3nM 2,000-fold more potently than Chk2 with IC50 value of 0.7?M.

CHIR-124
A8394-50	ApexBio	50 mg	EUR 537
Description: CHIR-124, a selective inhibitor, inhibits Chk1 with IC50 value of 0.3nM 2,000-fold more potently than Chk2 with IC50 value of 0.7?M.

FPA 124
B7222-10	ApexBio	10 mg	EUR 241

FPA 124
B7222-25	ApexBio	25 mg	EUR 457

FPA 124
B7222-5	ApexBio	5 mg	EUR 158

EUK 124
C4679-10	ApexBio	10 mg	EUR 132

PTC-124
9421-10	Biovision		EUR 142

PTC-124
9421-50	Biovision		EUR 414

EUK-124
2174-25	Biovision		EUR 262

EUK-124
2174-5	Biovision		EUR 109

Human Sickle tail protein homolog, SKT ELISA KIT
ELI-18163h	Lifescience Market	96 Tests	EUR 824

miRZip-124 anti-miR-124 microRNA construct
MZIP124-PA-1	SBI	Bacterial Streak	EUR 684

hCRP FRET 96
CH1021-96	Mediomics	1 Kit	EUR 455

hCRP TRF 96
CHTR1021-96	Mediomics	1 Kit	EUR 482

hInsulin FRET 96
IH1017-96	Mediomics	1 Kit	EUR 455

hInsulin TRF 96
IHTR1017-96	Mediomics	1 Kit	EUR 482

hAlbumin FRET 96
AH1005-96	Mediomics	1 Kit	EUR 455

hAlbumin TRF 96
AHTR1005-96	Mediomics	1 Kit	EUR 482

mIgG TRF 96
MIGTR1020-96	Mediomics	1 Kit	EUR 482

rIgG FRET 96
RI1024-96	Mediomics	1 Kit	EUR 455

Skt ELISA Kit| Mouse Sickle tail protein ELISA Kit
EF014796	Lifescience Market	96 Tests	EUR 689

HSP70 ELISA Kit
SKT-105-96	Cusabio	1 plate of 96 wells	EUR 581
Description: Sandwich ELISA kit used for quantitate HSP70 concentration in Cell Lysates, Tissue, Serum, Urine samples from Human, Goat, Dog

HSC70 ELISA Kit
SKT-106-96	Stressmarq	1 plate of 96 wells	EUR 717
Description: Sandwich ELISA kit used for quantitate HSC70 concentration in Cell Lysates, Tissue, Serum, Whole Blood samples from Human, Avian

HSP90 alpha ELISA Kit
SKT-107-96	Stressmarq	1 plate of 96 wells	EUR 685
Description: Sandwich ELISA kit used for quantitate HSP90 alpha concentration in Cell Lysates, Tissue, Serum, Whole Blood samples from Human, Goat, Avian

HSP70 ELISA Kit (High-Sensitivity)
SKT-108-96	Stressmarq	1 plate of 96 wells	EUR 685
Description: Sandwich ELISA kit used for quantitate HSP70 concentration in Serum, Plasma, Cell Lysates, Tissue samples from Human, Monkey, Dog, Rat, Mouse

HSP27 ELISA Kit
SKT-109-96	Stressmarq	1 plate of 96 wells	EUR 585
Description: Sandwich ELISA kit used for quantitate HSP27 concentration in Serum, Plasma, Cell Lysates, Tissue samples from Human

HSP60 ELISA Kit
SKT-110-96	Stressmarq	1 plate of 96 wells	EUR 585
Description: Sandwich ELISA kit used for quantitate HSP60 concentration in Cell Lysates, Tissue, Serum samples from Human

HO-1 ELISA Kit
SKT-111-96	Stressmarq	1 plate of 96 wells	EUR 585
Description: Sandwich ELISA kit used for quantitate HO-1 concentration in Cell Lysates, Tissue, Serum, Cyst fluid samples from Human, Rat

HSP65 ELISA Kit
SKT-113-96	Stressmarq	1 plate of 96 wells	EUR 633
Description: Sandwich ELISA kit used for quantitate M bovis/M tuberculosum HSP65 concentration in human samples in Cell Lysates, Tissue, Serum samples from M bovis, M tuberculosum

Alpha B Crystallin ELISA Kit
SKT-123-96	Stressmarq	1 plate of 96 wells	EUR 717
Description: Sandwich ELISA kit used for quantitate alpha B crystallin concentration in Cell Lysates, Tissue, Serum samples from Human

Nitrotyrosine ELISA Kit
SKT-126-96	Stressmarq	1 plate of 96 wells	EUR 460
Description: Competitive ELISA kit used for quantitate Nitrotyrosine in Plasma, Serum, Cell Lysates, Urine samples from all species

Rat GRP78 ELISA Kit
SKT-137-96	Stressmarq	1 plate of 96 wells	EUR 632
Description: Sandwich ELISA kit used for quantitate GRP78 concentration in rat samples in Tissue samples from Rat

Dibromo-tyrosine ELISA Kit
SKT-140-96	Stressmarq	1 plate of 96 wells	EUR 566
Description: Competitive ELISA kit used to quantify free and protein-bound 3,5-dibromotyrosine in Plasma, Urine samples from all species

Cortisol EIA Kit
SKT-201-96	Stressmarq	1 plate of 96 wells	EUR 329
Description: Competitive EIA kit used for quantitative measuring cortisol present in Dried Fecal Samples, Saliva, Urine, Serum, EDTA Plasma, Heparin Plasma, Tissue Culture Media samples from all species

Glutathione Detection Kit
SKT-202-96	Stressmarq	1 plate of 96 wells	EUR 428
Description: Direct Fluorometric detection assay to measure the total GSH content in Whole Blood, Serum, EDTA Plasma, Heparin Plasma, Erythrocytes, Urine, Cell Lysates, Tissue samples from all species

Glutathione S-Transferase Activity Kit
SKT-203-96	Stressmarq	1 plate of 96 wells	EUR 428
Description: Enzyme Activity Fluorometric assay used for quantitative measuring the activity of glutathione S-transferase in Urine, Serum, EDTA Plasma, Heparin Plasma, Cell Lysates samples from Human, Mollusk, Fish

Glutathione Reductase Activity Kit
SKT-204-96	Stressmarq	1 plate of 96 wells	EUR 428
Description: Enzyme Activity Fluorometric assay used for measuring glutathione reductase activity by the amount of GSH generated from the reduction of GSSG, in Serum, EDTA Plasma, Heparin Plasma, Erythrocytes, Cell Lysates samples from Human

Corticosterone EIA Kit
SKT-205-96	Stressmarq	1 plate of 96 wells	EUR 355
Description: Sandwich EIA kit used to measure the corticosterone present in Serum, EDTA Plasma, Heparin Plasma, Urine, Tissue Culture Media, Dried Fecal Samples samples from all species

Cortisone CLIA Kit
SKT-206-96	Stressmarq	1 plate of 96 wells	EUR 467
Description: Sandwich CLIA kit used for quantitative measuring the cortisone present in Dried Fecal Samples, Serum, Saliva, Urine, Plasma, Tissue Culture Media samples from all species

Prostaglandin E2 EIA Kit
SKT-207-96	Stressmarq	1 plate of 96 wells	EUR 527
Description: Sandwich EIA kit used for quantitative measuring PGE2 present in Saliva, Urine, Serum, EDTA Plasma, Heparin Plasma, Tissue Culture Media samples from all species

Cyclic AMP CLIA Kit (High-Sensitivity)
SKT-208-96	Stressmarq	1 plate of 96 wells	EUR 494
Description: Direct CLIA kit used for quantitative measuring cAMP present in Cell Lysates, Tissue, Saliva, Urine, EDTA Plasma, Heparin Plasma, Tissue Culture Media samples from all species

Cyclic AMP EIA Kit
SKT-209-96	Stressmarq	1 plate of 96 wells	EUR 454
Description: Direct EIA kit used for quantitative measuring cAMP present in Cell Lysates, Tissue, Saliva, Urine, EDTA Plasma, Heparin Plasma, Tissue Culture Media samples from all species

Cyclic GMP CLIA Kit (High-Sensitivity)
SKT-210-96	Stressmarq	1 plate of 96 wells	EUR 520
Description: Direct CLIA kit used to measure cGMP present in Cell Lysates, Tissue, Saliva, Urine, EDTA Plasma, Tissue Culture Media samples from all species

Cyclic GMP EIA Kit
SKT-211-96	Stressmarq	1 plate of 96 wells	EUR 474
Description: Direct EIA kit used for quantitative measuring cGMP present in Cell Lysates, Tissue, Saliva, Urine, EDTA Plasma, Tissue Culture Media samples from all species

Nitric Oxide Detection Kit
SKT-212-96	Stressmarq	2 plates of 96 wells	EUR 342
Description: Indirect Colorimetric assay used for quantitative measuring Nitrate and Nitrite present in a variety of samples in Serum, Plasma, Urine, Saliva, Water, Buffer, Cell Lysates, Tissue Culture Media samples from all species

Retinol Binding Protein Urinary EIA Kit
SKT-218-96	Stressmarq	1 plate of 96 wells	EUR 527
Description: Sandwich EIA kit used to measure RBP levels in urine samples in Urine samples from Human, Rat, Dog, Monkey

Cystatin C EIA Kit
SKT-219-96	Stressmarq	1 plate of 96 wells	EUR 494
Description: Sandwich EIA kit used to measure cystatin C levels in Serum, EDTA Plasma, Heparin Plasma, Urine, Tissue Culture Media samples from Human

Tissue Culture Plate, 96 Well
TCP20-96	Bio Basic	1 UNIT	EUR 53.48

Aligned Nanofibers 96 Well Plate
3D00012-96	Neuromics	700 nm-PCLs	EUR 110

Bridge-It cAMP-PDE 96
PD1016-96	Mediomics	1 Kit	EUR 455

Rat Coiled coil domain containing protein 124(CCDC124) ELISA kit
E02C1430-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A sandwich ELISA for quantitative measurement of Rat Coiled coil domain containing protein 124(CCDC124) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Coiled coil domain containing protein 124(CCDC124) ELISA kit
E04C1430-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A sandwich ELISA for quantitative measurement of Rabbit Coiled coil domain containing protein 124(CCDC124) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Coiled coil domain containing protein 124(CCDC124) ELISA kit
E03C1430-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A sandwich ELISA for quantitative measurement of Mouse Coiled coil domain containing protein 124(CCDC124) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Coiled coil domain containing protein 124(CCDC124) ELISA kit
E01C1430-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A sandwich ELISA for quantitative measurement of Human Coiled coil domain containing protein 124(CCDC124) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Coiled coil domain containing protein 124(CCDC124) ELISA kit
E07C1430-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A sandwich ELISA for quantitative measurement of Porcine Coiled coil domain containing protein 124(CCDC124) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Coiled coil domain containing protein 124(CCDC124) ELISA kit
E06C1430-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A sandwich ELISA for quantitative measurement of Goat Coiled coil domain containing protein 124(CCDC124) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Coiled coil domain containing protein 124(CCDC124) ELISA kit
E09C1430-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A sandwich ELISA for quantitative measurement of Monkey Coiled coil domain containing protein 124(CCDC124) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Coiled coil domain containing protein 124(CCDC124) ELISA kit
E08C1430-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A sandwich ELISA for quantitative measurement of Canine Coiled coil domain containing protein 124(CCDC124) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

AKT1 (Ab-124) Antibody
CSB-PA919481-	Cusabio		EUR 335
Description: A polyclonal antibody against AKT1 (Ab-124). Recognizes AKT1 (Ab-124) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:3000

AKT1 (Ab-124) Antibody
CSB-PA919481-100ul	Cusabio	100ul	EUR 316
Description: A polyclonal antibody against AKT1 (Ab-124). Recognizes AKT1 (Ab-124) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:3000

Akt (Ab-124) Antibody
33129-100ul	SAB	100ul	EUR 252

Akt (Ab-124) Antibody
33129-50ul	SAB	50ul	EUR 187

bcl-2(124) Antibody
BNC040530-100	Biotium	100uL	EUR 199
Description: Primary antibody against bcl-2(124), CF405S conjugate, Concentration: 0.1mg/mL

bcl-2(124) Antibody
BNC040530-500	Biotium	500uL	EUR 544
Description: Primary antibody against bcl-2(124), CF405S conjugate, Concentration: 0.1mg/mL

bcl-2(124) Antibody
BNC470530-100	Biotium	100uL	EUR 199
Description: Primary antibody against bcl-2(124), CF647 conjugate, Concentration: 0.1mg/mL

bcl-2(124) Antibody
BNC470530-500	Biotium	500uL	EUR 544
Description: Primary antibody against bcl-2(124), CF647 conjugate, Concentration: 0.1mg/mL

bcl-2(124) Antibody
BNCAP0530-100	Biotium	100uL	EUR 199
Description: Primary antibody against bcl-2(124), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

bcl-2(124) Antibody
BNCAP0530-500	Biotium	500uL	EUR 544
Description: Primary antibody against bcl-2(124), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

bcl-2(124) Antibody
BNCB0530-100	Biotium	100uL	EUR 199
Description: Primary antibody against bcl-2(124), Biotin conjugate, Concentration: 0.1mg/mL

bcl-2(124) Antibody
BNCB0530-500	Biotium	500uL	EUR 544
Description: Primary antibody against bcl-2(124), Biotin conjugate, Concentration: 0.1mg/mL

bcl-2(124) Antibody
BNC810530-100	Biotium	100uL	EUR 199
Description: Primary antibody against bcl-2(124), CF680R conjugate, Concentration: 0.1mg/mL

bcl-2(124) Antibody
BNC810530-500	Biotium	500uL	EUR 544
Description: Primary antibody against bcl-2(124), CF680R conjugate, Concentration: 0.1mg/mL

bcl-2(124) Antibody
BNC700530-100	Biotium	100uL	EUR 199
Description: Primary antibody against bcl-2(124), CF770 conjugate, Concentration: 0.1mg/mL

bcl-2(124) Antibody
BNC700530-500	Biotium	500uL	EUR 544
Description: Primary antibody against bcl-2(124), CF770 conjugate, Concentration: 0.1mg/mL

bcl-2(124) Antibody
BNC880530-100	Biotium	100uL	EUR 199
Description: Primary antibody against bcl-2(124), CF488A conjugate, Concentration: 0.1mg/mL

bcl-2(124) Antibody
BNC880530-500	Biotium	500uL	EUR 544
Description: Primary antibody against bcl-2(124), CF488A conjugate, Concentration: 0.1mg/mL

bcl-2(124) Antibody
BNC940530-100	Biotium	100uL	EUR 199
Description: Primary antibody against bcl-2(124), CF594 conjugate, Concentration: 0.1mg/mL

bcl-2(124) Antibody
BNC940530-500	Biotium	500uL	EUR 544
Description: Primary antibody against bcl-2(124), CF594 conjugate, Concentration: 0.1mg/mL

bcl-2(124) Antibody
BNC610530-100	Biotium	100uL	EUR 199
Description: Primary antibody against bcl-2(124), CF660R conjugate, Concentration: 0.1mg/mL

bcl-2(124) Antibody
BNC610530-500	Biotium	500uL	EUR 544
Description: Primary antibody against bcl-2(124), CF660R conjugate, Concentration: 0.1mg/mL

bcl-2(124) Antibody
BNC680530-100	Biotium	100uL	EUR 199
Description: Primary antibody against bcl-2(124), CF568 conjugate, Concentration: 0.1mg/mL

bcl-2(124) Antibody
BNC680530-500	Biotium	500uL	EUR 544
Description: Primary antibody against bcl-2(124), CF568 conjugate, Concentration: 0.1mg/mL