Vector & Virus

Epitope and Paratope Mapping by HDX-MS Combined with SPR Elucidates the Difference in Bactericidal Activity of Two Anti-NadA Monoclonal Antibodies

Epitope and Paratope Mapping by HDX-MS Combined with SPR Elucidates the Difference in Bactericidal Activity of Two Anti-NadA Monoclonal Antibodies

Characterization of antigen-antibody interactions is essential for understanding antibody-mediated safety towards pathogens, biopharmaceutical growth, in addition to analysis of the immune response put up vaccination. Bexsero is a multicomponent vaccine towards Neisseria meningitidis serogroup B through which one of many key vaccine antigens is Neisserial adhesin A (NadA), a trimeric coiled-coil protein. Two NadA-specific monoclonal antibodies (mAbs) …

Epitope and Paratope Mapping by HDX-MS Combined with SPR Elucidates the Difference in Bactericidal Activity of Two Anti-NadA Monoclonal Antibodies Read More »

Identification of a novel protective human monoclonal antibody, LXY8, that targets the key neutralizing epitopes of staphylococcal enterotoxin B

Identification of a novel protective human monoclonal antibody, LXY8, that targets the key neutralizing epitopes of staphylococcal enterotoxin B

Staphylococcal enterotoxin B (SEB), one of many exotoxins produced by Staphylococcus aureus, is the important thing toxin that causes poisoning reactions and poisonous shock syndrome. Within the present analysis work, a novel human antibody named LXY8 was screened from a human phage show antibody library, and LXY8 blocked the interplay between SEB and the T …

Identification of a novel protective human monoclonal antibody, LXY8, that targets the key neutralizing epitopes of staphylococcal enterotoxin B Read More »

Rational Design of a Pan-Coronavirus Vaccine Based on Conserved CTL Epitopes

Rational Design of a Pan-Coronavirus Vaccine Based on Conserved CTL Epitopes

With the speedy international unfold of the Coronavirus Illness 2019 (COVID-19) pandemic, a protected and efficient vaccine in opposition to human coronaviruses (HCoVs) is believed to be a prime precedence within the subject of public well being. As a result of frequent outbreaks of various HCoVs, the event of a pan-HCoVs vaccine is of nice …

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Immunoinformatics analysis to design novel epitope based vaccine candidate targeting the glycoprotein and nucleoprotein of Lassa mammarenavirus (LASMV) using strains from Nigeria

Immunoinformatics analysis to design novel epitope based vaccine candidate targeting the glycoprotein and nucleoprotein of Lassa mammarenavirus (LASMV) using strains from Nigeria

Lassa mammarenavirus (LASMV) is answerable for a particular sort of acute viral hemorrhagic fever generally known as Lassa fever. Lack of efficient therapies and counter-measures towards the virus has resulted in a excessive mortality fee in its endemic areas. Subsequently, on this research, a novel epitope-based vaccine has been designed utilizing the strategies of immunoinformatics …

Immunoinformatics analysis to design novel epitope based vaccine candidate targeting the glycoprotein and nucleoprotein of Lassa mammarenavirus (LASMV) using strains from Nigeria Read More »

Development of multi-epitope peptide-based vaccines against SARS-CoV-2

Development of multi-epitope peptide-based vaccines against SARS-CoV-2

Extreme acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has precipitated a pandemic involving so excess of 32 million infections and 980,031 deaths. Efficient vaccines are urgently wanted to stop SARS-CoV-2 infections. No vaccines have but been accepted for licensure by regulatory businesses. Although host immune responses to SARS-CoV-2 infections are starting to be unravelled, efficient clearance …

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