Month: May 2021

Epitope and Paratope Mapping by HDX-MS Combined with SPR Elucidates the Difference in Bactericidal Activity of Two Anti-NadA Monoclonal Antibodies

Epitope and Paratope Mapping by HDX-MS Combined with SPR Elucidates the Difference in Bactericidal Activity of Two Anti-NadA Monoclonal Antibodies

Characterization of antigen-antibody interactions is essential for understanding antibody-mediated safety towards pathogens, biopharmaceutical growth, in addition to analysis of the immune response put up vaccination. Bexsero is a multicomponent vaccine towards Neisseria meningitidis serogroup B through which one of many key vaccine antigens is Neisserial adhesin A (NadA), a trimeric coiled-coil protein. Two NadA-specific monoclonal antibodies (mAbs) …

Epitope and Paratope Mapping by HDX-MS Combined with SPR Elucidates the Difference in Bactericidal Activity of Two Anti-NadA Monoclonal Antibodies Read More »