Epitope and Paratope Mapping by HDX-MS Combined with SPR Elucidates the Difference in Bactericidal Activity of Two Anti-NadA Monoclonal Antibodies

Epitope and Paratope Mapping by HDX-MS Combined with SPR Elucidates the Difference in Bactericidal Activity of Two Anti-NadA Monoclonal Antibodies

Characterization of antigen-antibody interactions is essential for understanding antibody-mediated safety towards pathogens, biopharmaceutical growth, in addition to analysis of the immune response put up vaccination. Bexsero is a multicomponent vaccine towards Neisseria meningitidis serogroup B through which one of many key vaccine antigens is Neisserial adhesin A (NadA), a trimeric coiled-coil protein. Two NadA-specific monoclonal antibodies (mAbs) remoted from Bexsero-vaccinated people have been proven to have related binding affinity and seem to acknowledge the same antigen area, but solely one of many mAbs is bactericidal.
On this examine, we use hydrogen/deuterium alternate mass spectrometry (HDX-MS) to carry out an in-depth examine of the interplay of the 2 mAbs with NadA antigen utilizing a mixed epitope and paratope mapping technique. As well as, we use floor plasmon resonance (SPR) to research the stoichiometry of the binding of the 2 mAbs to NadA. Whereas epitope mapping solely identifies a transparent binding impression of one of many mAbs on NadA, the paratope mapping analyses exhibits that each mAbs are binding to NadA by way of a number of complementarity figuring out areas spanning each heavy and light-weight chains.
Our outcomes spotlight the benefit of mixed epitope and paratope mapping HDX-MS experiments and supporting biochemical experiments to characterize antigen-antibody interactions. By this mixed method, we offer a rationale for the way the binding stoichiometry of the 2 mAbs to the trimeric NadA antigen can clarify the distinction in bactericidal exercise of the 2 mAbs.

The Function of β Cell Stress and Neo-Epitopes within the Immunopathology of Kind 1 Diabetes

As a consequence of their secretory operate, β cells are predisposed to greater ranges of endoplasmic reticulum (ER) stress and larger sensitivity to irritation than different cell varieties. These stresses elicit modifications in β cells that alter their operate and immunogenicity, together with faulty ribosomal initiation, post-translational modifications (PTMs) of endogenous β cell proteins, and various splicing. A number of printed experiences verify the presence of not solely CD8+ T cells, but in addition autoreactive CD4+ T cells inside pancreatic islets.
Though the specificities of T cells that infiltrate human islets are incompletely characterised, they’ve been confirmed to incorporate neo-epitopes which are shaped by way of stress-related enzymatic modifications of β cell proteins. This text summarizes rising data about stress-induced modifications in β cells and knowledge supporting a job for neo-antigen formation and cross-talk between immune cells and β cells that provokes autoimmune assault – resulting in a breakdown in tissue-specific tolerance in topics who develop kind 1 diabetes.

Autoantibodies towards the immunodominant sCha epitope discriminate the chance of sudden loss of life in continual Chagas cardiomyopathy

In Chagas illness (ChD) brought on by Trypanosoma cruzi, new biomarkers to foretell continual cardiac pathology are urgently wanted. Earlier research in chagasic sufferers with gentle symptomatology confirmed that antibodies towards the immunodominant R3 epitope of sCha, a fraction of the human primary helix-loop-helix transcription issue like 5, correlated with cardiac pathology.
Epitope and Paratope Mapping by HDX-MS Combined with SPR Elucidates the Difference in Bactericidal Activity of Two Anti-NadA Monoclonal Antibodies
To validate sCha as a biomarker and to know the origin of anti-sCha antibodies, we carried out a multicenter examine with a number of cohorts of chagasic sufferers with extreme cardiac symptomatology. We discovered that ranges of antibodies towards sCha discriminated the excessive danger of sudden loss of life, indicating they could possibly be helpful for ChD prognosis. We investigated the origin of the antibodies and carried out an alanine scan of the R3 epitope.
We recognized a minimal epitope MRQLD, and a BLAST search retrieved a number of T. cruzi antigens. 5 of the hits had identified or putative capabilities, of which phosphonopyruvate decarboxylase confirmed the best cross-reactivity with sCha, confirming the function of molecular mimicry within the growth of anti-sCha antibodies. Altogether, we show that the event of antibodies towards sCha, which originated by molecular mimicry with T. cruzi antigens, might discriminate electrocardiographic alterations related to a excessive danger of sudden loss of life.

N-terminal transmembrane-helix epitope tag for x-ray crystallography and electron microscopy of small membrane proteins

Structural research of membrane proteins, particularly small membrane proteins, are related to well-known experimental challenges. Complexation with monoclonal antibody fragments is a typical technique to reinforce such proteins; nevertheless, producing antibody fragments that particularly bind a goal protein just isn’t trivial. Right here we establish a helical epitope, from the membrane-proximal exterior area (MPER) of the gp41-transmembrane subunit of the HIV envelope protein, that’s acknowledged by a number of well-characterized antibodies and that may be fused as a contiguous extension of the N-terminal transmembrane helix of a broad vary of membrane proteins.
To research whether or not this MPER-epitope tag may support structural research of small membrane proteins, we decided an X-ray crystal construction of a membrane protein goal that doesn’t crystallize with out the help of crystallization chaperones, the Fluc fluoride channel, fused to the MPER epitope and in advanced with antibody. We additionally show the utility of this method for single-particle electron microscopy with Fluc and two further small membrane proteins that signify totally different membrane protein folds, AdiC and GlpF.

Rabbit Chondroitin epitopes 5d4 ELISA kit

E04C0062-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Rabbit Chondroitin epitopes 5d4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Chondroitin epitopes 5d4 ELISA kit

E03C0062-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Mouse Chondroitin epitopes 5d4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Chondroitin epitopes 5d4 ELISA kit

E03C0062-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Mouse Chondroitin epitopes 5d4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Chondroitin epitopes 5d4 ELISA kit

E03C0062-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Mouse Chondroitin epitopes 5d4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Chondroitin epitopes 5d4 ELISA kit

E07C0062-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Porcine Chondroitin epitopes 5d4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Chondroitin epitopes 5d4 ELISA kit

E07C0062-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Porcine Chondroitin epitopes 5d4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Chondroitin epitopes 5d4 ELISA kit

E07C0062-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Porcine Chondroitin epitopes 5d4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Chondroitin epitopes 5d4 ELISA kit

E06C0062-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Goat Chondroitin epitopes 5d4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Chondroitin epitopes 5d4 ELISA kit

E06C0062-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Goat Chondroitin epitopes 5d4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Chondroitin epitopes 5d4 ELISA kit

E06C0062-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Goat Chondroitin epitopes 5d4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Chondroitin epitopes 5d4 ELISA kit

E08C0062-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Canine Chondroitin epitopes 5d4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Chondroitin epitopes 5d4 ELISA kit

E08C0062-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Canine Chondroitin epitopes 5d4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Chondroitin epitopes 5d4 ELISA kit

E08C0062-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Canine Chondroitin epitopes 5d4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Chondroitin epitopes 5d4 ELISA kit

E09C0062-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Monkey Chondroitin epitopes 5d4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Chondroitin epitopes 5d4 ELISA kit

E09C0062-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Monkey Chondroitin epitopes 5d4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Chondroitin epitopes 5d4 ELISA kit

E09C0062-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Monkey Chondroitin epitopes 5d4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Chondroitin epitopes 5d4 ELISA kit

E05C0062-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Guinea pig Chondroitin epitopes 5d4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Chondroitin epitopes 5d4 ELISA kit

E05C0062-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Guinea pig Chondroitin epitopes 5d4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Chondroitin epitopes 5d4 ELISA kit

E05C0062-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Guinea pig Chondroitin epitopes 5d4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Chondroitin epitopes 7d4 ELISA kit

E01C0061-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Human Chondroitin epitopes 7d4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Chondroitin epitopes 7d4 ELISA kit

E01C0061-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Human Chondroitin epitopes 7d4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Chondroitin epitopes 7d4 ELISA kit

E01C0061-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Human Chondroitin epitopes 7d4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Chondroitin epitopes 7d4 ELISA kit

E02C0061-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Rat Chondroitin epitopes 7d4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Chondroitin epitopes 7d4 ELISA kit

E02C0061-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Rat Chondroitin epitopes 7d4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Chondroitin epitopes 7d4 ELISA kit

E02C0061-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Rat Chondroitin epitopes 7d4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Chondroitin epitopes 7d4 ELISA kit

E04C0061-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Rabbit Chondroitin epitopes 7d4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Chondroitin epitopes 7d4 ELISA kit

E04C0061-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Rabbit Chondroitin epitopes 7d4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Chondroitin epitopes 7d4 ELISA kit

E04C0061-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Rabbit Chondroitin epitopes 7d4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Chondroitin epitopes 7d4 ELISA kit

E03C0061-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Mouse Chondroitin epitopes 7d4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Chondroitin epitopes 7d4 ELISA kit

E03C0061-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Mouse Chondroitin epitopes 7d4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Chondroitin epitopes 7d4 ELISA kit

E03C0061-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Mouse Chondroitin epitopes 7d4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Chondroitin epitopes 7d4 ELISA kit

E07C0061-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Porcine Chondroitin epitopes 7d4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Chondroitin epitopes 7d4 ELISA kit

E07C0061-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Porcine Chondroitin epitopes 7d4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Chondroitin epitopes 7d4 ELISA kit

E07C0061-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Porcine Chondroitin epitopes 7d4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Chondroitin epitopes 7d4 ELISA kit

E06C0061-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Goat Chondroitin epitopes 7d4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Chondroitin epitopes 7d4 ELISA kit

E06C0061-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Goat Chondroitin epitopes 7d4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Chondroitin epitopes 7d4 ELISA kit

E06C0061-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Goat Chondroitin epitopes 7d4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Chondroitin epitopes 7d4 ELISA kit

E08C0061-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Canine Chondroitin epitopes 7d4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Chondroitin epitopes 7d4 ELISA kit

E08C0061-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Canine Chondroitin epitopes 7d4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Chondroitin epitopes 7d4 ELISA kit

E08C0061-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Canine Chondroitin epitopes 7d4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Chondroitin epitopes 7d4 ELISA kit

E09C0061-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Monkey Chondroitin epitopes 7d4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Chondroitin epitopes 7d4 ELISA kit

E09C0061-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Monkey Chondroitin epitopes 7d4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Chondroitin epitopes 7d4 ELISA kit

E09C0061-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Monkey Chondroitin epitopes 7d4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Chondroitin epitopes 7d4 ELISA kit

E05C0061-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Guinea pig Chondroitin epitopes 7d4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Chondroitin epitopes 7d4 ELISA kit

E05C0061-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Guinea pig Chondroitin epitopes 7d4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Chondroitin epitopes 7d4 ELISA kit

E05C0061-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Guinea pig Chondroitin epitopes 7d4 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

ELISA kit for Mouse Gal (?-Galactosyl Epitopes)

E-EL-M1254 1 plate of 96 wells
EUR 534
Description: A sandwich ELISA kit for quantitative measurement of Mouse Gal (?-Galactosyl Epitopes) in samples from Serum, Plasma, Cell supernatant

ELISA kit for General Chondroitin sulfate

EK2180 96 tests
EUR 603
Description: Enzyme-linked immunosorbent assay kit for quantification of General Chondroitin sulfate in samples from serum, plasma, tissue homogenates and other biological fluids.

ELISA kit for Human Chondroitin sulfate proteoglycan 4

EK4319 96 tests
EUR 553
Description: Enzyme-linked immunosorbent assay kit for quantification of Human Chondroitin sulfate proteoglycan 4 in samples from serum, plasma, tissue homogenates and other biological fluids.

ELISA kit for General CS (Chondroitin Sulfate)

ELK8275 1 plate of 96 wells
EUR 372
Description: A competitive Inhibition ELISA kit for detection of Chondroitin Sulfate from General in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

ELISA kit for Human Chondroitin Sulfate Synthase 1 (CHSY1)

KTE62952-48T 48T
EUR 354
Description: Quantitative sandwich ELISA for measuring Human Chondroitin Sulfate Synthase 1 (CHSY1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human Chondroitin Sulfate Synthase 1 (CHSY1)

KTE62952-5platesof96wells 5 plates of 96 wells
EUR 2252
Description: Quantitative sandwich ELISA for measuring Human Chondroitin Sulfate Synthase 1 (CHSY1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human Chondroitin Sulfate Synthase 1 (CHSY1)

KTE62952-96T 96T
EUR 572
Description: Quantitative sandwich ELISA for measuring Human Chondroitin Sulfate Synthase 1 (CHSY1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

anti-PODXL (5D4)

LF-MA30568 100 ul
EUR 527
Description: Mouse Monoclonal to PODXL

Anti-FH (5D4)

YF-MA13015 100 ug
EUR 363
Description: Mouse monoclonal to FH

Anti-Frataxin (5D4)

YF-MA13120 100 ug
EUR 363
Description: Mouse monoclonal to Frataxin

Anti-MAP3K4 (5D4)

YF-MA14210 100 ug
EUR 363
Description: Mouse monoclonal to MAP3K4

Human Chondroitin sulfate ELISA kit

E01C0829-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Human Chondroitin sulfate in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Chondroitin sulfate ELISA kit

E01C0829-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Human Chondroitin sulfate in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Chondroitin sulfate ELISA kit

E01C0829-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Human Chondroitin sulfate in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

ELISA kit for Mouse Chondroitin sulfate proteoglycan 4

EK4318 96 tests
EUR 553
Description: Enzyme-linked immunosorbent assay kit for quantification of Mouse Chondroitin sulfate proteoglycan 4 in samples from serum, plasma, tissue homogenates and other biological fluids.

ELISA kit for Rat Chondroitin sulfate proteoglycan 4

EK5112 96 tests
EUR 553
Description: Enzyme-linked immunosorbent assay kit for quantification of Rat Chondroitin sulfate proteoglycan 4 in samples from serum, plasma, tissue homogenates and other biological fluids.

Custom Antibody titration by ELISA up to 2 rabbits and 1 bleed

ELISA-1 1
EUR 202

ELISA kit for Human MCSP (Melanoma Associated Chondroitin Sulfate Proteoglycan)

E-EL-H2413 1 plate of 96 wells
EUR 534
Description: A sandwich ELISA kit for quantitative measurement of Human MCSP (Melanoma Associated Chondroitin Sulfate Proteoglycan) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Human MCSP (Melanoma Associated Chondroitin Sulfate Proteoglycan)

ELK3075 1 plate of 96 wells
EUR 432
Description: A sandwich ELISA kit for detection of Melanoma Associated Chondroitin Sulfate Proteoglycan from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

Human chondroitin sulfate(CS)ELISA Kit

GA-E1912HM-48T 48T
EUR 289

Human chondroitin sulfate(CS)ELISA Kit

GA-E1912HM-96T 96T
EUR 466

Human chondroitin sulfate,CS ELISA Kit

201-12-1896 96 tests
EUR 440
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human chondroitin sulfate(CS)ELISA Kit

QY-E02240 96T
EUR 400

Human chondroitin sulfate,CS ELISA Kit

CN-04520H1 96T
EUR 449

Human chondroitin sulfate,CS ELISA Kit

CN-04520H2 48T
EUR 299

Human chondroitin sulfate, CS ELISA Kit

ELA-E0723h 96 Tests
EUR 824

ELISA kit for Rat CSPG5 (Chondroitin Sulfate Proteoglycan 5)

ELK7393 1 plate of 96 wells
EUR 432
Description: A sandwich ELISA kit for detection of Chondroitin Sulfate Proteoglycan 5 from Rat in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

Chondroitin Sulfate (CS) ELISA Kit

abx572082-96tests 96 tests
EUR 786

Chondroitin Sulfate (CS) ELISA Kit

abx350001-96tests 96 tests
EUR 786

Chondroitin Sulfate (CS) ELISA Kit

abx052801-96tests 96 tests
EUR 786

Chondroitin Sulfate (CS) ELISA Kit

20-abx258808
  • EUR 8443.00
  • EUR 4497.00
  • EUR 1036.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Chondroitin sulfate ELISA Kit (OKEH02554)

OKEH02554 96 Wells
EUR 779
Description: Description of target: Chondroitin sulfate readily interacts with proteins in the extracellular matrix due to its negative charges. These interactions are important for regulating a diverse array of cellular activities. The lecticans are a major part of the brain extracellular matrix, where the chondroitin sugar chains function to stabilize normal brain synapses as part of perineuronal nets. The levels of chondroitin sulfate proteoglycans are vastly increased after injury to the central nervous system where they act to prevent regeneration of damaged nerve endings. Although these functions are not as well characterized as those of heparan sulfate, new roles continue to be discovered for the chondroitin sulfate proteoglycans. Chondroitin sulfate is a sulfated glycosaminoglycan (GAG) composed of a chain of alternating sugars (N-acetylgalactosamine and glucuronic acid). It is usually found attached to proteins as part of a proteoglycan. A chondroitin chain can have over 100 individual sugars, each of which can be sulfated in variable positions and quantities. Chondroitin sulfate is an important structural component of cartilage and provides much of its resistance to compression. Along with glucosamine, chondroitin sulfate has become a widely used dietary supplement for treatment of osteoarthritis. ;Species reactivity: All;Application: ;Assay info: Assay Methodology: Quantitative Competitive ELISA;Sensitivity: 0.19 ng/mL

Rat Chondroitin sulfate ELISA kit

E02C0829-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Rat Chondroitin sulfate in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Chondroitin sulfate ELISA kit

E02C0829-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Rat Chondroitin sulfate in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Chondroitin sulfate ELISA kit

E02C0829-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Rat Chondroitin sulfate in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Chondroitin sulfate ELISA kit

E03C0829-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Mouse Chondroitin sulfate in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Chondroitin sulfate ELISA kit

E03C0829-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Mouse Chondroitin sulfate in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Chondroitin sulfate ELISA kit

E03C0829-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Mouse Chondroitin sulfate in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Chondroitin sulfate ELISA kit

E07C0829-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Porcine Chondroitin sulfate in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Chondroitin sulfate ELISA kit

E07C0829-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Porcine Chondroitin sulfate in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Chondroitin sulfate ELISA kit

E07C0829-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Porcine Chondroitin sulfate in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Chondroitin sulfate ELISA kit

E06C0829-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Goat Chondroitin sulfate in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Chondroitin sulfate ELISA kit

E06C0829-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Goat Chondroitin sulfate in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Chondroitin sulfate ELISA kit

E06C0829-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Goat Chondroitin sulfate in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Chondroitin sulfate ELISA kit

E04C0829-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Rabbit Chondroitin sulfate in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Chondroitin sulfate ELISA kit

E04C0829-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Rabbit Chondroitin sulfate in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
These research present that the MPER epitope offers a structurally outlined, inflexible docking website for antibody fragments that’s transferable amongst various membrane proteins and may be engineered with out prior structural data. Antibodies that bind to the MPER epitope function efficient crystallization chaperones and electron microscopy fiducial markers, enabling structural research of difficult small membrane proteins.